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Lab tests, including kidney function, blood pressure, and electrolyte levels, may be performed while you use Hydrochlorothiazide. The dosage is based on your medical condition and response to therapy. The effect on your blood sugar while taking Hydrochlorothiazide, as the dose of your antidiabetic medicine may need adjusting. This medicine is used to treat high blood pressure. Hydrochlorothiazide may increase blood glucose levels. Although there are no adequate and well-controlled studies using hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects. If you are or will be breast-feeding while you use Hydrochlorothiazide.